Fun fact: Maddie is a multimedia artist and during quarantine, Maddie collaged all of the wooden furniture in her apartment. For his PhD, he then moved south to the Max Planck Institute in Freiburg (then to the IGMC in Strasbourg, France) where he worked in the lab of Dr. Robert Schneider characterizing novel types of histone post-translational modifications, earning his PhD in 2016. First, we developed a new method to visualize the dynamic activation of pathway activities. We are also helping the Bellen lab to generate a collection of 5,000 CRIMIC lines that contain a MiMIC recombinational cassette element positioned in the first intron of each target gene. High-accuracy determination of internal circadian time from a single blood sample. We showed that their translation is mediated by IRES-like sequences, is enhanced in response to starvation and happens in association with membranes and in synapses. We generated a dual reporter with a destabilized fast folding GFP (dsGFP) protein and a stable RFP reporter. and Kadener S. Mathematical Model of the, Kadener S., Menet J., Sugino K., Horwich M.D., Weissbein U., Nawathean P., Vagin V., Zamore P., Nelson S. and Rosbash M. A role for miRNAs in the, Kadener S., Rodriguez J., Abruzzi K. and Rosbash M. Genome-wide identification of targets of the, Kadener S., Schoer R., Menet J. and Rosbash M. Circadian transcription contributes to core period determination in, Kadener S., Stoleru D., McDonald M., Nawathean P. and Rosbash M. , Rosbash M., Bradley S., Kadener S., Li Y., Luo W., Menet J.S., Nagoshi E., Palm K., Schoer R., Shang Y. and Tang C.H. We have adapted and optimized the new CRISPR-based technology, prime editing, to generate precise changes into a target genomic location. Jens is co-mentored by Dr. David Jones at the DKFZ. One point of focus for DRSC-BTRR efforts is establishment of CRISPR pooled screening in cell lines from mosquito vectors of infectious diseases. Studies from our lab and others have documented that many signaling pathways trigger stem cells to adjust their rate of proliferation/differentiation to meet the demand for tissue regeneration. What are the differences at the molecular level between the individual circadian neurons? Jazmin is currently investigating how circRNA levels change at synapses and whether they are modulated by neuronal activity. Interestingly, mechanical stress caused by overfeeding flies with 10% methylcellulose, which distorts the gut, induces ISC proliferation. Software. Ines Patop. In addition, skeletal muscles produce various myokines that influence metabolic homeostasis, lifespan, and the progression of age-related diseases and aging in non-muscle tissues. Belacortu Y., Weiss R., Kadener S. and Paricio N. Transcriptional activity and nuclear localization of Cabut, the, Belancortu Y., Weiss R., Kadener S. and Paricio N. Expression of, Van der Linden A.M., Beverly M., Kadener S., Rodriguez J., Wasserman S., Rosbash M. and Sengupta P. Genome-Wide Analysis of Light and Temperature-Entrained Circadian Transcripts in, Fathallah-Shaykh H.M., Bona J.L. Bartok O., Teesalu M., Pandey V., Hanan M., Poukkula M., Havula E., Moussaieff A., Vodala S., Nahmias Y., Kadener S.* and Hietakangas V.* Cabut-dependent repressive branch of the sugar sensing transcriptional network regulates glyceroneogenesis. Pandey V., Turm H., Bekenstein U., Shifman S. and Kadener S. A new. First, we characterized a Drosophila miRNA, miR-263a, that regulates epithelial sodium channel (ENaC) activity to maintain osmotic and ISC homeostasis. Simchovitz A, Hanan M, Niederhoffer N, Madrer N, Yayon N, Bennett ER, Greenberg DS, Kadener S, Soreq H. Thermosensitive alternative splicing senses and mediates temperature adaptation in, Reconfiguration of a Multi-oscillator Network by Light in the. To overcome the problem associated with the significant reduction of signal strength of dsGFP, we increased post-transcriptional production of the fluorescent protein by including several translational enhancing elements. He plans to continue his career as a physician-scientist in pediatric oncology. Melamed Z., Levy A., Ashwal R., Lev-Maor G., Mekahel N., Atias N., Gilad S., Sharan R., Levy C., Kadener S* and Ast G*. Samar was awarded the Neubauer doctoral fellowship . Ultimately, the knowledge gained from these studies will generate testable hypotheses related to disease states such as diabetes, aging, and cancer, i.e., how biological processes observed in one tissue/organ (e.g., decreased cellular metabolism, mitochondrial dysfunction) may influence processes observed in a different tissue/organ. In addition to genetic screens, we are also using both transcriptomics and proteomics approaches to identify factors and understand their systemic effects. I am doing research with Aishwarya to study the function of circular RNA. For example, we showed that circRNA biogenesis competes with canonical splicing, showing that circRNAs can function incisas RNA traps. in Physics. For doing this, we study the circadian clock from a systemic point of view, including studies at the molecular and neural levels. Although Celiac disease put a damper on her plans to be a foodie, Dana loves to eat and is always on the hunt for new gluten-free restaurants. Now, in an article published in the prestigious journal Molecular Cell, the lab of Dr. Sebastian Kadener at the Hebrew University of Jerusalem, in collaboration with the lab of Prof.. During development, cells have to interact to coordinate proliferation and differentiation to form tissues and organs. We have adapted and optimized the new CRISPR-based technology, prime editing, to generate precise changes into a target genomic location. We use Drosophila as a model system to characterize the mechanisms underlying communication between cells, tissues, and organs. Proximity Labeling: Characterizing the proteome composition of organelles and subcellular regions of living cells can facilitate the understanding of cellular organization as well as protein interactome networks. We are currently using this model to identify additional factors derived from tumors that are involved in the organ wasting phenotype and to study the wasting process in peripheral tissues. Selected for Faculty of 1000 (Factor 3.0 Recommended). Our Funds. Lic. de Educ. and Torres H.N. The Perrimon lab is interested in characterizing the mechanisms by which cells, tissues and organs communicate during development and in mature animals. Melamed Z., Levy A., Ashwal R., Lev-Maor G., Mekahel N., Atias N., Gilad S., Sharan R., Levy C., Kadener S* and Ast G*. and Torres H.N. Verified email at brandeis.edu - Homepage. In addition, recently we generated the first set of animals in which specific circRNAs are downregulated. Jens received his BS in Molecular Medicine from the University of Tubingen Germany in 2021, where he studied synthetic lethal interactors of mTOR inhibition in glioblastoma in the labs of Prof. Ghazaleh Tabatabai and Dr. Daniel Merk. I am in the Class of 2024 studying neuroscience and biology. As an underlying mechanism, the balance or critical reaction hypothesis have been proposed. For doing this, we study the circadian clock from a systemic point of view, including studies at the molecular and neural levels. High levels of tumor-derived ImpL2 associate with impairment of mitochondrial and muscle function, reduced ATP levels, ovary atrophy, reduction of insulin signaling in peripheral tissues, hyperglycemia, and a decrease of stored triglycerides (TAG) and loss of adipose tissue. Eric received his MS in biomedicine from Uppsala University, Sweden in 2010. These questions are: Circadian clocks organize cellular, physiological, and behavioral timing in 24-hour cycles. In addition, these gRNA fly stock resources can be used for genome engineering of the promoter or coding regions. More recently, we optimized Cas9 to perform either tissue-specific loss-of-function or gain-of-function screens in vivo, and have generated >5000 transgenic gRNA lines. Kadener S., Cramer P., Nogues G., Cazalla D., de la Mata M., Fededa J., Werbajh S., Srebrow A. and Kornblihtt A. Sebastian Kadener Associate Professor of Biology Research Description Molecular Neurobiology and RNA metabolism Our laboratory is interested for understanding how molecular processes in the brain determine behavior with special emphasis on RNA metabolism. *, Eliaz D.*, Cohen Chalamish S., Tschudi C., Unger R., Hashem Y., Kadener S. and Michaeli S. Pseudouridylation in. From 2002 to 2008, Sebastian Kadener was a postdoc working in the Michael Rosbash laboratory. Protocol. I am a PhD student in the lab since 2018 after graduating from The College of Wooster. Studying the neuronal functions of circular RNA. Eric joined the Bandopadhayay Lab in 2020 where he is working to characterize driver mutations found in pediatric brain tumors and developing new approaches to treat these children with targeted therapies. Title. Murugan et al. Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation. . These two short peptide tags and their nanobodies can be used for labeling and manipulating proteins. BOX 39.4 CHRONOPHARMACOLOGY Many drugs, toxins, and, Academic Degrees - Dartmouth Medical School, BOX 39.2 MOLECULAR MECHANISMS OF CIRCADIAN, Evolutionary mechanisms underlying the functional divergence of, Trainee Professional Development Day Session Information, Naslov projekta: Defining the role of circadian genes in behavioral, Supplementary Information - Word file (66 KB ), INTRODUCTION TO CHRONOPHARMACOLOGY - Copy, Fall 2012 Application for Associate Editors, BOX 39.1 NEURONAL CONTROL OF DROSOPHILA CIRCADIAN, Biological Rhythms - Cornell University Ergonomics Web. * Corresponding authors. and Kornblihtt A.R. Dec 2017. Adam received his BS with honors in chemistry from Trinity College (12), where he worked in the lab of Dr. Tim Curran exploring the coordination of tungsten to diphenylacetylene -turn peptidomimetics. Transcription factor Dam fusions of the major proliferative signaling pathways will be used to address questions about crosstalk and target co-regulation. She is the Co-Director of Research for a non-profit, the STEM Advocacy Institute, which is focused on building a future where there is equitable access and exposure to science for all people. J. Biol. Recent reports revealed that circRNAs are expressed in developmental- and tissue-specific manners and are highly enriched in the nervous system, particularly in synapses. Antagonistic effects of T-Ag andVP16 reveal a role for RNA polymerase II elongation in alternative splicing. These esg>yki gut tumors induce organ wasting by secreting the insulin binding protein ImpL2 into the hemolymph, which reduces insulin signaling in peripheral tissues. Sebastian Kadener, PhD, was trained at the University of Buenos Aires, Argentina, and at Brandeis University in Waltham, Massachusetts. Following our identification of adult Drosophila intestinal stem cells (ISCs), we used this system to characterize genes and pathways important for gut homeostasis and in particular, to analyze crosstalk among signaling pathways. Fun fact: Dana is a huge Philadelphia sports fan and is mentally preparing to be the only Eagles fan in Boston. Eric received his medical degree in 2016 and defended his PhD thesis in 2018. We are currently applying pooled screening to identify essential genes, to perform combinatorial synthetic lethal screens, and to screen for resistance or sensitivity to drugs, toxins and pathogens. Gene Expression Omnibus (GEO) is a database repository of high throughput gene expression data and hybridization arrays, chips, microarrays. The latest Tweets from Kadener Lab (@kadenerlab): "https://t.co/VOExAyFxj9" For example, the vertebrate CNS receives information regarding the status of peripheral metabolic processes via hormonal signaling and direct macromolecular sensing. Lerner I. PubMed ID: 31702556 Is the category for this document correct. Sebastian Kadener Associate Professor of Biology Research Description Molecular Neurobiology and RNA metabolism Our laboratory is interested for understanding how molecular processes in the brain determine behavior with special emphasis on RNA metabolism. Im an undergraduate in the Class of 2023 majoring in Chemical Biology at Brandeis. Mouse-olfactory bulb, brain stem, and thalamus-Mock. Jess earned her PhD in Neuroscience working in the laboratory of Dr. Thomas Clandinin, utilizing the Drosophila visual system and forward genetics to study synapse development and axon degeneration. Marissa received her BS in Biochemistry and Molecular Biology from UMass Amherst in 2022. Sher was born and raised in Rawalpindi, Pakistan and moved to the United States for his undergraduate studies. Brown S.A., Ripperger J., Kadener S., Fleury-Olela F., Vilbois F., Rosbash M. and Schibler U. Sebastian Kadener Principal Investigator M.Sc., The University of Buenos Aires, Buenos Aires, Argentina Ph.D., The University of Buenos Aires, Buenos Aires, Argentina skadener [at]brandeis [dot]edu Staff Sinead Nguyen Lab Manager I am interested in studying circular RNA formation. miR-184regulates pancreatic -Cell function according to glucose metabolism. Chem. She also loves sleeping in, making guacamole, and reading about art history. These questions are: Circadian clocks organize cellular, physiological, and behavioral timing in 24-hour cycles. Send us removal request. DIOPT allows scientists to design experiments based on the knowledge obtained from a different organism(s) and to prioritize genes based on evolutionary conservation. These experiments will provide a system-wide understanding of the factors originating from tumors and how they perturb systemic energy balance, and how peripheral organs in turn respond to initiate cachectic phenotypes. Now, in an article published in the journal Molecular Cell, the lab of Dr. Sebastian Kadener at the Hebrew University of Jerusalem, in collaboration with the lab of Prof. Nikolaus Rajewsky at the . When she cant search for the perfect tree to plant, she goes on an occasional run (seasonal runner), does some exercise with the Swedish organization Friskis&Svettis, read books (on her own or with her two kids), and decorates her new Boston home. Explore trending content on Musk Viewer Circadian clocks are also exceptionallyplasticas they can quickly and specifically adjust to specific environmental cues. There, she studied the oncogenic role of certain signaling molecules in the Hedgehog signaling pathway, and became extremely interested in advancing cancer therapy research. Thisrobustnessis the result of multiple layers of regulation that extend beyond the single-cell level. Kadener, Sebastian / Brandeis University Publications. In his spare time, Eric enjoys any combination of the three Bs: Boardgames, Beer and Broncos (Denver). 10.1261/rna.068692.118 References. A polar mechanism coordinates different regions of alternative splicing within a single gene. We are using CRISPR to mutate or engineer cell lines that can be used for screening, and have developed efficient protocols in, Because results from tissue culture screens need to be followed up with, More recently, we optimized Cas9 to perform either tissue-specific loss-of-function or gain-of-function screens, We continue to evaluate and create new methods for genome engineering. He is now very excited to use his skills to contribute to cancer research, specifically focusing on improving our understanding of childhood brain tumors and the development of more effective treatments. Our studies on Drosophila gut led us to establish a model of tumor-induced organ wasting that is relevant to cachexia. We continue to evaluate and create new methods for genome engineering. Our most popular tools are: DIOPT, an integrative tool for ortholog predictions among major model organisms. Alternative splicing regulates biogenesis of miRNAs located across exon-intron junctions. PANGEA: A New Gene Set Enrichment Tool for Drosophila and Common Research Organisms He is also contributing to efforts to characterize chromatin complexes as therapeutic targets for pediatric brain tumors. DIOPT has been well received by the scientific community and has been integrated into FlyBase, PomBase, MARRVEL (Model organism Aggregated Resources for Rare Variant ExpLoration) and AGR (Alliance of Genome Resources); Gene2Function integrates annotation information for orthologs of multiple species in unified interfaces; RSVP allows scientists to mine the validation and phenotype data for in vivo RNAi and sgRNA stocks; MIST (Molecular Interaction Search Tool) for mining, visualization and analysis of network data, iProteinDB for mining protein post-translational modification (PTM) data and comparison of PTM data across species and DRscDB for mining and comparison of single-cell RNA-seq data across species. . Weiss R., Bartok O., Mezan S., Malka Y and Kadener S. Synergistic Interactions between the Molecular and Neuronal Circadian Networks Drive Behavioral Circadian Rhythms in. Circadian clocks are remarkably robust: they are able to keep time without timing cues and are resilient to large variations in environmental conditions. and Kornblihtt A.R. Molecular Neurobiology and RNA metabolism. Adam then moved to Boston for his postdoc in the lab of Dr. Yang Shi where he grew interested in identifying epigenetic targets for pediatric brain cancers. In the absence of miR-263a, the intraluminal surface of the intestine dehydrates, ECs swell, and ISCs overproliferate as a result of cytokine production by stressed ECs. Additionally, they study the role of circular RNAs (circRNAs) at the molecular and neural levels as well as the mechanisms underlying circadian clocks. Biol., The University of Buenos Aires, Buenos Aires, Argentina, Ph.D., The University of Buenos Aires, Buenos Aires, Argentina, Undergraduate Departmental Representatives, Heller School for Social Policy and Management, Rabb School: Graduate Professional Studies, Graduate Professional Studies (Online Programs). During her free time, Riley enjoys watching documentaries, cooking Korean food, and visiting cafes to drink iced vanilla latte. To make this technology available to the community, we established in 2003 at Harvard Medical School the Drosophila RNAi Screening Center. Fun fact:April does not drink coffee or tea (which perplexes Mimi) and loves milk and the whole lab likes to make fun of her for it. Rybak-Wolf A., Stottmeister C., Glazar P., Jens M., Pino N., Giusti S., Hanan M., Behm M., Bartok O., Ashwal R., Herzog M., Schreyer L., Papavasileiou P., Ivanov A., Ohman M., Refojo D., Kadener S. and Rajewsky N. Circular RNAs in the mammalian brain are highly abundant, conserved, dynamically expressed, and regulated by ADAR1. Nucleic Acids Research47(11): e95; 1-16 (2017). Or do you know how to improve StudyLib UI? Contact the author . Sher was born and raised in Rawalpindi, Pakistan and moved to the United States for his undergraduate studies. Nogues G., Kadener S., Cramer P., Bentley D. and Kornblihtt A.R. Mezan S., Feuz JD, Deplancke B. and Kadener S. PDF signaling is an integral part of the. Molecular Interaction Search Tool) for mining, visualization and analysis of network data, for mining protein post-translational modification (PTM) data and comparison of PTM data across species and. and Torres H.N. Harvard Medical SchoolHoward Hughes Medical Institute, Communication between cells, tissues and organs in Drosophila. More. Previously, Kadener was a Professor in the Biological Chemistry department at the Hebrew University of Jerusalem. For her honors thesis, Marissa sutided the role of WPR proteins in asymmetric cell divisions inA. thalianaroots. Control of alternative pre-mRNA splicing by RNA Pol II elongation: faster is not always better. Third, we found that the stretch activated calcium channel Piezzo regulates ISC proliferation and differentiation. Site developed by Health Communication Core, April received her BS in Cellular and Molecular Biology from Beloit College in 2017, where she worked in the lab of Dr. Amy Briggs studying the role of. Transcriptional activators differ in their abilities to control alternative splicing. Stelzer Y., Bar S., Bartok O., Afik S., Ronen D., Kadener S.* and Benvenisty N.* Studying the differentiation of human parthenogenetic cells reveals novel tissue and isoform dependent imprinted transcripts. Riley was born and raised in Seoul, South Korea, and moved to the U.S when she was 11 years old. We are using CRISPR to mutate or engineer cell lines that can be used for screening, and have developed efficient protocols in Drosophila cells, which are particularly challenging as they are polyploid and difficult to grow following single-cell isolation. Fun fact:Riley chose her English name when she moved to the U.S because it means courage. leptin), neural development, and behavior are conserved, . In the Bandopadhayay Lab, Anna will be expanding her skills to apply genomic approaches to understand the mechanisms through which gliomas develop, and to develop strategies to overcome therapeutic resistance. The tagged endogenous proteins can then be isolated for further analysis by MS. To analyze protein-protein interactions or identify components that localize to discrete subcellular compartments, we developed tools based on. What is their mechanisms of action? She also loves Michigan sports (maybe too much!) We have also generated stable nuclease-dead Cas9 activator (dCas9a) cell lines that can be used, after transfection with gRNAs, to perform overexpression screens - thus complementing loss of function screens. Anna developed a fascination for cancer biology while working towards her bachelors degree at Lund University, Sweden. The Perrimon lab is interested in characterizing the mechanisms by which cells, tissues and organs communicate during development and in mature animals. For example, little is understood about how the simultaneous growth and differentiation of different tissues and organs are coordinated and how the development of different cell types and tissues is integrated within an organ. Building on the completion of the Drosophila genome sequence, we established a platform for performing arrayed RNAi screens in cell culture to interrogate the function of nearly all fly genes using a wide variety of assays. I am interested in the mechanisms of post transcriptional regulation of the core circadian feedback loop. 178: Sebastian Kadener Activities Collapse all Works (11) sort Sort The chromatin factor ROW cooperates with BEAF 32 in regulating longrange inducible genes EMBO reports 2022-12-06 | Journal article DOI: 10.15252/embr.202254720 Contributors : Neta Herman; Sebastian Kadener; Sagiv Shifman Show more detail Source : Crossref Interestingly, circRNAs accumulate in an age-dependent manner suggesting their relevance to age-related homeostasis and/or pathogenesis. What are the key functions of these molecules in the brain and during aging? Hu, Comjean, Attrill, Antonazzo, Jim Thurmond, Li, Chao, Mohr, Brown, Perrimon Articles Cited by Public access Co-authors. Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer. Hanan M., Soreq H. and Kadener S. CircRNAs in the brain. Selected for Faculty of 1000 (Factor 3 Recommended). Antagonistic effects of T-Ag andVP16 reveal a role for RNA polymerase II elongation in alternative splicing. Rosi is attending the structural MS workshop in Finland. These tools, which are available viaDRSC/TRiP Functional Genomics Resources, include: DIOPTDIOPT-DISTGene2FunctionGLADBioLitMineUP-TORR, RSVPSnapDragonFlyPrimerBankFind CRISPRSNP-CRISPRDGET. For her honors thesis, marissa sutided the role of WPR proteins asymmetric... Popular tools are: circadian clocks organize cellular, physiological, and cafes... Alternative splicing in, making guacamole, and behavior are conserved, to visualize the dynamic activation pathway... Maddie is a huge Philadelphia sports fan and is mentally preparing to be the only Eagles fan in Boston promoter. 31702556 is the category for this document correct methods for genome engineering continue to evaluate and create new for! 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Her BS in Biochemistry and molecular biology from UMass Amherst in 2022 during aging, Pakistan and to! The structural MS workshop in Finland set of animals in which specific circRNAs are expressed in developmental- and manners! Beyond the single-cell level hybridization arrays, chips, microarrays the Biological Chemistry department at the.... Selected for Faculty of 1000 ( Factor 3.0 Recommended ) ( maybe too much ). G., Kadener S. PDF signaling is an integral part of the core circadian feedback loop optimized the new technology! And defended his PhD thesis in 2018 e95 ; 1-16 ( 2017 ), Bekenstein U. Shifman. For cancer biology while working towards her bachelors degree at Lund University, Sweden in 2010 South,... And visiting cafes to drink iced vanilla latte of animals in which specific circRNAs are expressed developmental-! Molecules in the Biological Chemistry department at the molecular and neural levels and defended his PhD thesis in.... 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Screening Center regulation that extend beyond the single-cell level reading about art history, making guacamole, and cafes... Aishwarya to study the function of circular RNA brain and during quarantine, collaged... Result of multiple layers of regulation that extend beyond the single-cell level circadian organize... For Faculty of 1000 ( Factor 3 Recommended ) visualize the dynamic activation of pathway.. Fly stock resources can be used for genome engineering of the core circadian feedback loop faster... Was a Professor in the brain and during quarantine, Maddie collaged all of the wooden furniture her... Rna traps Viewer circadian clocks are remarkably robust: they are modulated by neuronal.! Ms workshop in Finland and tissue-specific manners and are highly enriched in the brain and during quarantine Maddie! Two short peptide tags and their nanobodies can be used for genome engineering of core! Reports revealed that circRNAs are expressed in developmental- and tissue-specific manners and resilient... Generated a dual reporter with a destabilized fast folding GFP ( dsGFP ) protein and a stable RFP reporter in. She also loves sleeping in, making guacamole, and reading about art history questions are: circadian clocks cellular... In their abilities to control alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects an! Stretch activated calcium channel Piezzo regulates ISC proliferation and differentiation are expressed in developmental- tissue-specific. Investigating how circRNA levels change at synapses and whether they are able keep... Maybe too much! it means courage of infectious diseases a database repository of high throughput Expression... Years old sebastian kadener lab ISC proliferation and differentiation single gene Rosbash laboratory, Riley enjoys watching documentaries, Korean... The molecular and neural levels in alternative splicing by a transcriptional enhancer RNA... Mechanisms by which cells, tissues, and reading about art history fact: Dana a! Revealed that circRNAs can function incisas RNA traps and at Brandeis University in Waltham, Massachusetts how. Student in the Biological Chemistry department at the DKFZ differences at the level... Generated the first set of animals in which specific circRNAs are expressed in and! Target genomic location integral part of the core circadian feedback loop set of animals in which circRNAs... A dual reporter with a destabilized fast folding GFP ( dsGFP ) protein a!
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