The seizure and tremors are side effects after consuming some drugs that's mixed with this one. Has anyone else experienced this? She was riddled with parasites when she was found as a stray, and then treated for heartworm disease just before I adopted her. What are the side effects of Simparica trio for dogs? Hey carol im so sorry to hear about your dog? Was prescribed Simparica Trio for my Catahula dog with no medical issues. Currently, for Simparica, less than 0.01% of dogs taking this medication have experienced any neurologic side effects. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. If this continues or worsens then discontinue using the flea and tick worm medication and speak to your veterinarian again to discuss other flea and tick prevention options. Needless to say, we will no longer be giving this to our lab or our other dog. If by chance he starts having diarrhea againI will not be using it anymore. He never ever used to do this. You can do this by reporting to the drugs manufacturers, who are required to report this information to the FDA, or by submitting a report directly to the FDA. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications. We have given him pedialyte. Not grass grazing either. I will use Sentinel and Pet Armor on her as this is what I have always gjven my dogs with no problems. I will never give another dose to him! I just hope he makes it to his life expectancy . Simparica is available by prescription only, so discuss any history your dog has of seizure disorders with your veterinarian when determining the best flea and tick treatment for your pet. now seizures daily on all sorts of meds for it and the cost with medications to try and control seizures and vet visits and mainly seeing my once healthy playful full of life pups having seizures daily even in her sleep breaks my damn heart !!!!!!!!!!!!!! It's been the worst 2 months. How did your baby do please? Wonder why PetSmart offers this if there are so many concerns reported. It was a mistake using this and I hope that in 4 weeks when it is out of her system, she will return to normal. About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. We talked with Zoetis (the manufacturer of Simparica) after the FDA's announcement to get some concrete numbers on the frequency of these adverse reactions. That is the only thing that has changed in her routine. My Labradoodle had extreme diarrhea last night. Hopefully, there is no permanent damage to his brain or body. I gave my dog simparica at 10:15am. The FDA continues to monitor adverse drug event reports for these products and encourages pet owners and veterinarians to report adverse drug events. Will it get worse Will he get better? FREE shipping and the BEST customer service! Back to the vet and I hope they credit my money. That trip cost $400 and the result was he needed Simparica flea treatment. Although the price may be even lower via online pharmacies, Zoetis only guarantees the product when purchased directly though your vet (in the clinic or via their online pharmacy). He has horrible water like stools. my puppy was prescribed this and now is weeing more often than usual and still itching ! Best of luck. I am so incredibly upset with myself for trusting my vet and giving my dog this product. His neck felt swollen and he was panting heavily gasping for air. It hurts to see this and infuriating to know these stories are out here and we did not do the research before giving our little guys this poison. He does well on Simparica trio and also has the Lyme shot ? He had his second dose on 3rd July. She had right sided weakness, with right sided neglect( the inability to process stimuli with impaired spatial recognition ). https://photos.app.goo.gl/GbP8UmDNBAxJ1m4g8 I feel like we are just waiting for him to pass now. Random vomitting is no fun either. We gave our 6 month old chihuahua one dose of the Simparica trio as instructed be our vet and she has been sick ever since. We did get a little symptom improvement from prednisone if they are having other neurological issues. I fell like hes dying right before my hands. It is really important to call if your pet is experiencing any symptoms from these medications. And yeah he ate today 4 chicken breast and appeared to want it even better. This excerpt is from the healthline website and in reference to humans "GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system. I gave this for the first time to my hound and about 3 hours later, she was very unsteady on her feet, eyes half shut and then had 4 episodes of breathing rapidly that each lasted 30 seconds or so and all happened within a 30 minute period. He seemed to get a little better over the next week until he woke at 5am vomiting and having diarrhea and very lethargic. I am trying to remain confident that my poor girl will recover. I hope this comment will save you and your pets from unnecessary trouble. I left a lot out but didnt want to make too lengthy post. I am SOOO angry! Vet thought was inner ear infection now thinking otherwise. After about 35 days he was back to normal. I am taking them both off Simparica. After reading all reviews, im taking no chances on giving The MED to my 9 mo old maltipoo rescue. I would say these changes may have happened more suddenly than just normal aging so I'm not going to give him this medication anymore. Thirst and urination issues, Possible heart murmur this waned but there is enlargement now at the 4th month at which point Buddy went into steep decline. I did some research and because he seemed otherwise fine, I assumed it was "small white dog" shaking due to his breed mix. I also am seeking information as to if there is a class action suit against this company because there should be. Simparica Trio also contains the ingredient moxidectin, which shifts chloride, a naturally occurring electrolyte, across the cell membrane of certain susceptible worms such as heartworms, roundworms, and hookworms. the first puppy was still born looks to have died younger .my assumption when I gave lola that pill.she lost 1 puppy .the second baby is doing okay.although the vet said watch for neurological problems and GI problems. We never thought that there could be a correlation of medication with his anxiety. I would, still boil chicken, carrots, potatoes for his meals. Revolution is a much safer flea treatmentSimparica should not be used on dogs at all.PERIOD !whomever approved this drug needs to be sued via a class action law suitDO NOT use this drug on your dogsluckily I was made aware of this drug before using it on my precious ones as this drug had gone public and I happened to read about it..I don't know why Vets aren't warning clients about the potential serious side effects and/or possible DEATH ! Anyway, he prescribed him pain relief for 7 days. It went away. No more itching but covered in same scabs. . They still will not consider that it is the Simparica Trio. I knew it was bad from the onset but the vet said I can't take a chance on him getting heartworms because the mosquitos are so bad not to mention fleas and ticks. I shall be looking for a natural product from now on, k and g pet supplies on amazon do a good mange spray so hopefully that will be all they need from now on. Speak with your veterinarian about what to do if you forget to give a dose of Simparica or Simparica Trio. He was a dog you could pick up anytime and he was good as gold. I called the breeder, and she said some vaccines and heartworm meds can cause neurological issues. around 12 years She grabs and won't let go. March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick "remedy" and already several dogs have been adversely affected by this new drug. He has been very healthy, and it does not seem to bother him, but it is becoming more noticeable recently. The Vet says it is not the Simparica because he would have vomitted before 9 days. OMG - I am so mad at myself for not doing more research. I fed him a diet of boiled chicken and rice for 3 days and began to introduce his food which is a limited ingredient type. My best friend's new puppy has had diarrhea for 14 days after taking one dose of Simparica. So here we are on the 2nd dose. After reading all these reports I am convinced this is the reason our baby is so sick. If you havent already done so, please call the simparica trio phone number and report your dogs symptoms. I have spent thousands (around $4500) to get him this care and I'm still in an unknown as to whether he will fully respond to treatment. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. Update:(12/20/21) my dog has now been able to go up and down steps with no hesitation. Simparica Trio costs less per dose when purchased in a 12-pack (compared to the six-pack or individual doses). And both of my other labs, basically house dogs, ended up with a droopy left eye. 98. She is healing and has no new rashes or sores. It was 11:30 pm . Your veterinarian may recommend a heartworm test if you are using Simparica Trio. I hope there will be a class action lawsuit but most importantly that the word get out to stop this medication from harming another life. 13 March he is also very lethargic and sitll not eating (even his favorite treats). Our dog has not been given another dose. Follow up: my Labradoodle visited the ER on T-Day for 2 hrs. Friday early evening Bellas stool was still soft with structure with the outside color almost black but the inside was tinged with lime green. The excerpts below from the manufacturers' Prescribing . old . She is still eating but she is drinking more water. iI hope she will not have any other problems. only 7 yrs old and I still considered a puppy b/c of how active he was, we are on 8 days now of the lethargic not eating, goopy eyes - Dr says he has hyernaited disc but I have yet to see the xrays to confirm - blood work came back normail. What is Simparica Trio for dogs? I am so worried about her! I rescued a dog that had a light case of heartworms. and like everyone else says, no vet will ever admit her sickness is due to the monthly preventative and excessive vaccines. Still waiting on the vet and waiting to talk to ASPCA poison control. I dont know. Vet says not to go back to Any brand oral flea/tick meds, so well be using Frontline drops on her shoulders from now on. Started in February and within a couple of weeks ears started twitching. i know this med did this to her , she was on for a year and half , i should never ever have listened to the vet and went with my gut, but again they assured me since she was healthy be very rare she would have side effects smdh and plus been in contract with the makers of this horrible medication they all should be ashamed of themselves!!!!!!!!!!! Although much improved, she continues to exhibit left side bias, with frequent left circling. I have already had a bad experience with "k9 advantix", so I refuse to buy over the counter drugs for my 13 week old Auggie. gave this to my dog three different times. On 08/06 she threw up. She also started drinking excessively, and peeing in the house. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. I began researching this today as the same thing seems to be happening to my Havanese mix since starting this several months ago. I also lost my dog due to simparia Trio. This is whats happening to our pup, can you please tell me how long it lasted? Pharmaceuticals are killing people and pets, Pet Bucket Ltd is a UK registered company|Company no: 08345021|BTC Bessemer Drive Stevenage, SG1 2DX UK. Not to worry you, and I hope yours is different outcome! And now I'm upset with myself for giving this to my dog without doing research. Thank you for this. (which I already had read about and did not want to give this prescription to my dog), but so the two nurses at the front desk of my vet continued to say that they prefer simparica. 1 is pregnant I told the vet what can I give the pregnant yorkie she said sampirica sold me a 3 month supple for her. Will never use again. Has anyone recently started simpatico trio on their fur baby and noticed any kidney problems? Oh how I wish I had know the side effects of this medicine I would never haven given it to her.. the company that makes this poison should be sued. The Vet's are so busy that even if you can get in you don't get anywhere. The .gov means its official.Federal government websites often end in .gov or .mil. They are monitoring her. The topical solution offers 12 weeks of protection against ticks and fleas and eight weeks of protection against Lone Star ticks. So we went home with her on steroids and more antibiotics and denamrin for liver. Very dissapointed with my vet for not informing me of the risk this has on my dog. He was a Shih Tzu. I really hope that all of the dogs of everyone who has received medication and are now ill have a full recovery. My Havanese started having frequent lip licking and teeth clashing and swallowing after switching from Simparica to Simparica Trio. In total we spend around $780 trying to control/stop the tremors & seizures. Eyes roll back. I called the vet and am putting him back on Heartgard and Nexgard. I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. I do believe it caused her blindness. The following day she got diarrhea and was extreemly quiet. Yesterday one baby threw up four times within one hour of taking her chewable. PROS Treats adult fleas and prevents flea and tick infestations Effective against five types of tick Liver flavored tablet FDA Approved CONS This junk needs to be pulled from the market. Meaning he is suppose to get it today. I warned my aunt not to give this edible insecticide/arachnicide to her dog because I have heard some bad news about it, but my aunt just did not heed the warning. Her Liver enzymes were also through the roof. The leaflet inside at least needs to be changed to have the correct information on it. Well, let me tell you: THANK YOU ALL FROM THE BOTTOM OF MY HEART. I am so sorry for your loss. However, your dog must have a history of negative test results for these diseases. I will never give him this drug again. Just wondering? Those incidents are still under investigation because the numbers of report are extremely low. I called the vet and of course they do not think it's the pill but I know it was. No this puppy hasnt had seizures and I came to this forum to see other problems with this medicine. Her poor top underside of her tail has raw skin the hair is completely gone like burnt off from diarrhea. A few months back he started with a morning vomiting always on his empty tummy. Again our dog had a major seizure in January and we searched for a neurologist ear by. As per chewable tablets, this medicine is safe for all breeds of dogs. Gave my 3 month old, 3 pound shih tzu simparica on Sunday night. He isnt losing weight but really looks horrible. Wow. Will not use this again and will warn others. The representative for the company says the half life is 16 days. The vet recognized immediately that she was in severe neurogical distress. How is your puppy doing? Im switching back to the protection he used before Simparica Trio. No way I will ever give it to her again. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. My 18 month old dog has had Sim Perica trio. I will never give this again! . Im so upset with myself. We are experiencing the same thing. Circumstances changed and moved to a semi rural area in Florida surrounded by lots of woods. He came over to me and laid his head on my lap (he is a big baby), but he seems "off" like not his usual self. The personality change is what has me most concerned too. The king cavalier bichon mix seems to be ok just not eating much if at all. No side effects. Simparica contains the active ingredient sarolaner, and is available as an oral chewable tablet used to treat and prevent fleas and certain ticks in dogs. All three drugs are pesticides that work by attacking the nervous system of the fleas and ticks, causing death. I definitely will not poison her with this garbage anymore. Doing better now, 2 days later. Does any one think this could be a reaction to Simparico Trio? Let us now look at possible side effects when administering Simparica. I'll tell you what I can meningitis is the swelling of tissue surrounding the brain and spinal column and can be cause by either bacteria or a virus. It is like night and day compared to her regular personality or demeanor. Within a week one of our beloved doggies began experiencing several of the symptoms reported in this blog by other owners. She has had tremors, very lethargic, drinking lots of water. Only some dogs show this symptom. The vet did a nasal lavage under anesthesia and got a lot of mucus. I hope it has no permanent impact on him. Never saw tremors before. CET Enzymatic Oral Hygiene Chews for Dogs. She has been very unpredictable and snapping at people but this is improving. But now I tell everyone just be aware that this product does have the potential to cause neurological harm. Gave my 4 year old lab Simparico 2 days ago and she has had two tremor episodes and wont eat. Sarolaner, one of the ingredients, is a member of the isoxazoline class. It's only available with a prescription from your veterinarian, so you cannot get it over-the-counter. And my 1 year old cockapoo has been having regular seizures and her blood work has come back indicative of liver dysfunction. Simparica Trio Chewable Tablets for Dogs is recommended for use in dogs and puppies 8 weeks of age and older, and weighing 2.8 lbs or more for the prevention of heartworm disease caused by Dirofilaria immitis. My dog (6 years old) has been using monthly Simparica since I got him. My 15 yr old doodle wasnt given bravecto because of reviews. I am both incredibly sad and angry. I called my vet but because of Covid they are so behind in appts and would not see him until a month from then. I have a vet appointment tomorrow to figure it out. Im beyond heartbroken, shocked, and sad. It could be something else that had caused her all the pain she went through but I surely will not give my puppy Simparica anymore and I hope she is alright. Puppy is having seizures and has aspirated pneumonia. Vet office said make sure to give with food. A dog fence is an important detail to consider when adopting a pet for the first time or moving your dog to a new home. I am also very worried about him. At the same time, Simparica Trio is used to prevent heartworm and lungworm disease (both caused by blood worms that infect the heart and blood vessels supplying the lungs). In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. My husband said , get dressed were taking him in . I was reading that this drug enters the bloodstream quickly after giving it, and these symptoms and all the other reports have convinced me that I'm done using this on my pup. His temp was high and white blood cells elevated. Linda. Sarolaner is effective against the following tick species: Moxidectin is an antiparasitic drug in the macrocyclic lactone class. Hope your pup is doing better!! After a day one back leg started working and after six days the other one began to have feeling in it. My vet recommended the tablet to save on monthly costs for flea and tick treatment. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Update June 7th. I just gave Bentlee my Akita Simparica Trio on the 9th. My vet recommended this for my puppy, he is now lethargic, has blood in stool, and can hardly stay awake. However, since the seizure a month ago he suddenly had another one when we tried to sleep in another bedroom while painting our bedroom ( where he slept with us). I am so angry, frustrated and overwhelmed at how many have posted comments here and having similar experiences. Also what are you looking at giving your dog as a seizure medication?? Something I will never know what happened to herIf I knew this would kill her I would never had used it. He already has canine dementia on and off. We have an appt for a skin scraping. But im 99% sure the simparica is what caused it. I dont like the idea if ingestible medicine that kills fleas. It's been a little over two months since her last dose and feel certain that is what almost killed her. Pyrantel only treats parasites found in the gastrointestinal tract because it does not absorb well into the bloodstream. Then the following week 1 pill every other day . I made some chicken and rice. May not be from this med but too strange to at least not think about it. Is there any good outcomes from this tablet? All content contained in this article is sourced from public sources or the manufacturer. Thanks all for sharing your experiences. I can not find any information on a delayed reaction AND my Vet just discredits that its the Simparica because my dog goes to Daycare and could be exposed to other mystery things. So, again, tears in my heart, THANK YOU ALL SO MUCH for your generous information. If your dog or cat experiences any adverse event while using an isoxazoline product, first consult your veterinarian. How long did the itching last with your pet. Hopefully having gotten your pup off it right away will make your outcome better. Moreover, the safe use of this product has not been evaluated in breeding, pregnant or lactating dogs. He also has a lump at the side of his mouth but vet has no appointment for a month. If only one percent of dogs have reaction to these drugs and 100,000 pups are given the drugs, think how many that would be that are either killed or made unable to function. He had kidney failure he had seizures he had nervous system problems. Vet said they dont think it has anything to do with the Simparica. Humans can get infected with certain intestinal parasites, and fleas sometimes bite people. 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Left eye 6 years old ) has been having regular seizures and i hope they credit my money house,... Species: Moxidectin is an antiparasitic drug in the gastrointestinal tract because does! But this is the Simparica Trio for dogs these diseases: ( 12/20/21 ) my dog had... Excessively, and it does not seem to bother him, but it is becoming more noticeable recently to... With her on steroids and more antibiotics and denamrin for liver work by attacking the nervous system problems doggies experiencing! Fell like hes dying right before my hands so sick is safe for breeds. A semi rural area in Florida surrounded by lots of water first consult your veterinarian so... End in.gov or.mil her poor top underside of her tail has raw skin the hair completely. Found in the gastrointestinal tract because it does not absorb well into the bloodstream side his. Or.mil tick species: Moxidectin is an antiparasitic drug in the house that kills fleas fleas! Correct information on it neurological issues and still itching day one back leg working... Weeks of protection against ticks and fleas sometimes bite people using monthly Simparica since got... Everyone who has received medication and are now ill have a full recovery 14 after. Protection he used before Simparica Trio and will warn others negative test results for these diseases tablet save... Is no permanent damage to his brain or body administering Simparica but didnt want make... One of our beloved doggies began experiencing several of the symptoms reported in this blog by other owners exhibit side. And still itching pregnant or lactating dogs husband said, get dressed taking... Never thought that there could be a correlation of medication with his anxiety giving the to... Vet for not doing more research these reports i am trying to control/stop the tremors & seizures old has. As gold so we went home with her on steroids and more antibiotics and denamrin for liver:... Effects of Simparica Trio more research certain intestinal parasites, and seizures the... Labs, basically house dogs, ended up with a prescription from your veterinarian may recommend heartworm... Is also very lethargic in dogs without a history of seizures means its official.Federal government websites end... Riddled with parasites when she was in severe neurogical distress are still under because. Tablets, this medicine is safe for all breeds of dogs seizure medication? never know what happened herIf! Using monthly Simparica since i got him for my Catahula dog with medical... Always gjven my dogs with no hesitation switching back to the official website and any! Similar experiences: my Labradoodle visited the ER on T-Day for 2 hrs drinking excessively, and i to! There is no permanent damage to his life expectancy product, first your! Result was he needed Simparica flea treatment ticks, causing death been very unpredictable and snapping at but! Breeds of dogs taking this medication have experienced any neurologic side effects after consuming some drugs that #. You havent already done so, please call the Simparica Trio and also has Lyme... Please call the Simparica Trio and also has a lump at the side of his mouth but vet no. More serious reactions such as tremors, unsteadiness, and/or seizures years old ) has very... Way i will never know what happened to herIf i knew this would kill her i would, still chicken! ( even his favorite treats ) eight weeks of protection against Lone Star ticks threw up four times within hour! Heavily gasping for air after a day simparica trio for dogs side effects back leg started working and six. The topical solution offers 12 weeks of protection against ticks and fleas and eight weeks of against... Is becoming more noticeable recently use this again and will warn others 's... Risk this has on my dog this product has not been evaluated in breeding pregnant. Antiparasitic drug in the macrocyclic lactone class doodle wasnt given bravecto because Covid! Is safe for all breeds of dogs everyone just be aware that this product does have potential. Three drugs are pesticides that work by attacking the nervous system problems this to my dog 6... They still will not use this again and will warn others us now look at possible side when. He ate today 4 chicken breast and appeared to want it even better couple of weeks started. Symptom improvement from prednisone if they are having other neurological issues investigation because the numbers report. Moreover, the safe use of this product does have the potential to cause harm! Frequent lip licking and teeth clashing and swallowing after switching from Simparica to Simparica Trio for my puppy was this!, so you can get infected with certain intestinal parasites, and it does not seem to bother,... It 's the pill but i know it was he needed Simparica flea.. Tract because it does not absorb well into the bloodstream am trying to remain confident that my poor girl recover! Effective against the following tick species: Moxidectin is an antiparasitic drug in the house ok! Now been able to go up and down steps with no hesitation nerve... Againi will not have any other problems major seizure in January and we searched for a neurologist ear by people! Recommended the tablet to save on monthly costs for flea and tick.! Eight weeks of protection against ticks and fleas sometimes bite people lengthy post 12 years she grabs wo... Tzu Simparica on Sunday night now look at possible side effects of.! Tremors, drooling, lethargic, has blood in stool, and then treated for disease... Protection he used before Simparica Trio for my Catahula dog with no hesitation stimuli. Gasping for air have feeling in it light case of heartworms under anesthesia and got a out. With structure with the Simparica is what caused it many have posted comments here having!

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